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7-Hydroxymitragynine (often abbreviated as 7-OH or 7-HO) is an alkaloid found in the leaves of the Kratom plant (Mitragyna speciosa), which is native to Southeast Asia. Here’s a breakdown of what it is:
Chemical Nature: It is an oxidized derivative of mitragynine, which is the most abundant alkaloid in Kratom. 7 Hydroxymitragynine is formed through the metabolic process of mitragynine in the body, primarily via the liver’s cytochrome P450 enzymes.
Pharmacological Effects:
Opioid Activity: 7 Hydroxymitragynine may act as an agonist at the mu-opioid receptor, much like traditional opioids, but it can also interact with delta and kappa opioid receptors. It has a higher affinity and potency at the mu-opioid receptor compared to mitragynine.
Analgesia: It’s known for its strong pain-relieving properties, often cited as being significantly more potent than mitragynine and even morphine in some studies.
Other Effects: Besides pain relief, it may contribute to mood enhancement and sedation, depending on the dose.
Use and Products:
Kratom Products: 7 Hydroxymitragynine is naturally present in Kratom leaves but in much smaller quantities compared to mitragynine. Some newer Kratom products or extracts are specifically formulated to enhance the concentration of 7 hydroxymitragynine, marketed for their potent effects.
Potential Risks: Due to its potency, there’s a concern about dependency and withdrawal with regular use. It’s also a subject of debate in terms of safety and regulation, with some regions considering or implementing bans or controls on Kratom and its derivatives due to potential health risks.
Research and Controversy:
While there’s ongoing research into its effects, safety profile, and potential therapeutic uses, much of the data comes from animal studies, and human clinical research is limited. This has led to a mix of anecdotal claims, scientific interest, and regulatory scrutiny.
Legal Status: The legal status of 7 hydroxymitragynine varies by country and can change, often influenced by the broader debate on Kratom’s legal status. It’s important for users to check local laws.
In summary, 7 Hydroxymitragynine is a key component of Kratom’s psychoactive profile, particularly noted for its analgesic effects, but it comes with considerations regarding safety, dependency, and legal status.
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7 Hydroxymitragynine is primarily used for its potent analgesic (pain-relieving) properties, derived from the Kratom plant. It’s sought after for alleviating chronic pain due to its high affinity for mu-opioid receptors, offering an alternative to traditional pain medications. Additionally, it’s noted for potential mood enhancement and as an aid in managing opioid withdrawal symptoms, though its use is controversial and subject to legal restrictions in some areas.
Consult with a professional health care provider to determine if this product is right for you, and if so, how to use it safely. Improper use can result in abuse, dependence, addiction, overdose, and death. Do not take more than one serving within a 24 hour period. This product is not intended to diagnose, treat, cure or prevent any disease.
DO NOT USE if pregnant, planning to become pregnant, breastfeeding, or have any medical condition.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease
This product is not available for shipment to the following states: Alabama, Arkansas, Indiana, Georgia, Oklahoma, Rhode Island, Wisconsin; or the following counties: Sarasota County (Florida), San Diego (California), Oceanside (California), Alton (Illinois), Jerseyville (Illinois), Edwardsville County (Illinois), Columbus (Mississippi), Union County (Mississippi), Ascension (Louisiana), Franklin (Louisiana), Rapides (Louisiana)
